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  • 研发团队在国际上极具影响力的学会和期刊上发表多项重要的研究成果。

    瑞齐替尼 I期临床:

     

    1. A Phase I Study to Evaluate Safety, Tolerability, Pharmacokinetics and Antineoplastic Activity of BPI-7711 in Patients with EGFR/T790M Mutation Advanced or Recurrent NSCLC 

    (BPI-7711瑞齐替尼 I 期临床中期分析研究成果)
    I期poster
     

    发表于:

    ASCO 2019 poster

    2. Safety, Efficacy, and Pharmacokinetics of Rezivertinib (BPI-7711) in Patients With Advanced NSCLC With EGFR T790M Mutation: A Phase 1 Dose-Escalation and Dose-Expansion Study

    (BPI-7711瑞齐替尼 I 期临床研究成果)
    I期文章PDF
     

    发表于:

    Journal of Thoracic Oncology  2022 May;17(5), 708–717.

    瑞齐替尼 IIa期临床(一线):

       

    1. A phase IIa study to evaluate safety and efficacy of Rezivertinib (BPI-7711) in locally advanced or metastatic/recurrent treatment-naïve NSCLC patients with EGFR mutation

    (瑞齐替尼的IIa期临床研究成果)
    IIa期poster
      发表于:
    ESMO 2022 poster

    2. Results of the phase IIa study to evaluate the efcacy and safety of rezivertinib (BPI-7711) for the frst-line treatment of locally advanced or metastatic/recurrent NSCLC patients with EGFR mutation from a phase I/IIa study

    (瑞齐替尼的IIa期临床研究成果)
    IIa期文章PDF
     

    发表于:

    BMC Medicine 2023 Jan 8;21(1):11.

    瑞齐替尼 IIb期注册临床(二线):

       

    1. Efficacy and safety of Rezivertinib (BPl-7711) in patients with locally advanced or metastatic/recurrent EGFR T790M mutated NsCLC: a phase Ilb, multicenter, single-arm, open-label study

    (瑞齐替尼的IIb期注册临床研究成果)
    IIb期poster
     

    发表于:

    ASCO 2022 poster

    2. Efficacy and safety of Rezivertinib (BPI-7711) in patients with locally advanced or metastatic/recurrent EGFR T790M mutated NSCLC: a phase IIb study

    (瑞齐替尼的IIb期注册临床研究成果)
    IIb期文章PDF
     

    发表于:

    Journal of Thoracic Oncology 2022 Nov;17(11):1306-1317.

    3. Central nervous system efficacy of rezivertinib (BPI-7711) in advanced NSCLC patients with EGFR T790M mutation: A pooled analysis of two clinical studies.

    (瑞齐替尼的二线脑转移疗效汇总分析成果)
    脑转移文章PDF
     

    发表于:

    Lung Cancer 2023 Jun:180:107194.

    瑞齐替尼 III期注册临床(一线):

       

    1. Rezivertinib versus gefitinib as first-line therapy for patients with EGFR-mutated locally advanced or metastatic non-small-cell lung cancer (REZOR): a multicentre, double-blind, randomised, phase 3 study

    (瑞齐替尼的III期注册临床研究成果)
    III期文章PDF
     

    发表于:

    The Lancet Respiratory Medicine
    2025 Feb 3.